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US 8,709,500 B2Granted
Drug delivery system
AssigneeIsis Innovation Limited
InventorDermot Michael O'Hare
Life of this patent
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Abstract
A drug delivery system for the controlled release of a pharmaceutically-active compound by oral route comprises an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group. A preferred layered double hydroxide is one that has layers which comprise [LiAl2(OH)6]+. The drug delivery system has use in the delivery of drugs such as 4-biphenylacetic acid, Diclofenac, Gemfibrozil, Ibuprofen, Naproxen, 2-Propylpentanoic acid and Tolfenamic acid.
Claims20
A method comprising:
- orally administering to a subject a formulation comprising:
- a drug delivery system comprising an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group;
- and
- a non-toxic compound comprising an anion configured to intercalate between the layers in the layered double hydroxide in preference to the pharmaceutically-active compound and release the pharmaceutically-active compound in the subject's stomach by displacing the pharmaceutically-active compound from the layers in the layered double hydroxide.
1 more element
Dependencies are inferred from the claim text.