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US 8,709,487 B1Granted
Nanoparticle entrapment of materials
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsMark K. Kinnan, Heidi L. Schreuder-Gibson
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Abstract
A water-based and surfactant-free microwave synthesis of polymer nanoparticles includes the entrapment of diisopropyl fluorophosphatase (DFPase) within poly(4-vinylpyridine) (PVP) nanoparticles. The resulting nanoparticles are approximately 80-100 nm in diameter and reactive activity of DFPase is maintained after encapsulation.
Claims15
A method of synthesis comprising:
- preparing a reagent mixture in a reaction vessel, the reagent mixture maintaining at least two separated phases and comprising:
- a monomer mixture comprising at least one monomer to be polymerized,
- an aqueous initiator solution, and
- a material to be entrapped, and
- irradiating the reagent mixture with microwave radiation to obtain nanoparticles with entrapped materials;
- wherein the nanoparticles with entrapped materials are synthesized using 30 to 110 W of microwave power, 1 to 6 minutes of microwave radiation, and 0.01 to 0.75 M concentration of the monomer mixture.
3 more elements
A method of synthesis comprising:
- preparing a reagent mixture in a reaction vessel, the reagent mixture maintaining at least two separated phases and comprising:
- a monomer to be polymerized,
- an aqueous initiator solution, and
- an enzyme;
- irradiating the reagent mixture with microwave radiation to obtain nanoparticles with encapsulated enzyme;
- wherein the nanoparticles with encapsulated enzyme are synthesized using 30 to 110 W of microwave power, 1 to 6 minutes of microwave radiation, and a 0.01 to 0.75 M monomer concentration of the reagent mixture.
3 more elements
Dependencies are inferred from the claim text.