Pharmaceutical compositions of entacapone, levodopa and carbidopa with improved bioavailability
AssigneeWockhardt Limited
InventorsMunish Talwar, Ritesh Kapoor, Manoj Mashalkar, Girish Kumar Jain
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Abstract
The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200®. The invention also relates to processes for making such compositions.
Claims12
A single oral dose pharmaceutical composition comprising a combination of entacapone, levodopa and carbidopa, or salts thereof wherein the entacapone has been co-micronized with one or more sugar alcohols prior to mixing with other active ingredients, wherein the co-micronized entacapone and sugar alcohol mixture so obtained has a mean particle size of less than 30μ.
Dependencies are inferred from the claim text.