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US 8,709,484 B2Granted
Phospholipid-based powders for drug delivery
AssigneeNovartis AG
InventorsJeffry G. Weers, Thomas E. Tarara, Luis A. Dellamary, Jean G. Riess, Ernest G. Schutt
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Abstract
Phospholipid based powders for drug delivery applications are disclosed. The powders may include a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.
Claims19
A method for producing a phospholipid particulate composition comprising:
- adding a polyvalent cation to a formulation comprising a phospholipid wherein a molar ratio of polyvalent cation to phospholipid is sufficient to increase a gel-to-liquid crystal transition temperature of the particles compared to particles without the polyvalent cation such that the particles have a gel-to-liquid crystal transition temperature that is greater than room temperature by at least 20 C;
- and
- drying said formulation to form a dry particulate composition comprising hollow and porous particles,
- wherein said dry particulate composition is characterized by being deliverable at an emitted dose of at least 54.55%.
1 more element
Dependencies are inferred from the claim text.