System for controlled release of an active principle and method for preparation
AssigneesCentre National De La Recherche Scientifique, Univeriste de Montpellier 1
InventorsMichel Vert, Laurent Leclercq, Mahfoud Boustta
Life of this patent
Estimating the term…
Abstract
A system for controlled release of an active principle, includes at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. A method for preparation of such a system is described. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P).
Claims15
A system for the controlled release of an active principle, the system consisting of:
- (a) a degradable polymer matrix able to form acid compounds when the polymer matrix is hydrolytically degraded, and
- (b) a polyelectrolytic complex of the active principle with a polyelectrolytic polymer partner of opposite net charge, wherein
- said active principle has at least one electrostatic charge and said polyelectrolytic partner has an opposite charge, said complex being stoichiometric in terms of opposite electric charges,
- said polyelectrolytic polymer partner is acid-sensitive and suitable of being degraded by said acid compounds formed when the polymer matrix is hydrolytically degraded, and
- said complex is incorporated within the degradable polymer matrix.
Dependencies are inferred from the claim text.