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US 8,709,480 B2Granted
Adhering composition and method of applying the same
AssigneeTechnion Research & Development Foundation Limited
InventorsHavazelet Bianco-Peled, Ohad Kimhi
Life of this patent
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Abstract
A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface.
Claims49
A composition comprising:
- a) a non-protein based pre-gel comprising at least one phenol-based compound, excluding phloroglucinol and its derivatives, and at least one water miscible polymer selected from at least one of the group consisting of a naturally existing form of a carbohydrate, a synthetically prepared form of a carbohydrate and a salt of an anionic polysaccharide;
- and
- b) a solid support comprising at least one cross-linking agent capable of interacting with said at least one water miscible polymer.
A composition comprising:
- a) a non-protein based pre-gel comprising at least one phenol-based compound, excluding phloroglucinol and its derivatives, at least one water miscible polymer selected from at least one of the group consisting of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide, and a cross-linking agent comprising at least one water-insoluble salt of multivalent ions capable of interacting with said at least one water miscible polymer,
- b) a solid support, and
- c) at least one trigger compound capable of triggering release of multivalent ions from the cross-linking agent into the pre-gel.
A method of in-situ adhering, comprising:
- providing a pre-gel that comprises a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of the group consisting of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide;
- spreading a layer of said pre-gel onto a first surface;
- adding a solid support comprising at least one cross-linking agent capable of interacting with said at least one water miscible polymer, to said pre-gel;
- and
- allowing said pre-gel to cure and adhere onto the first surface.
2 more elements
A method of in-situ adhering, comprising:
- providing a pre-gel that comprises at least one phenol-based compound, at least one water miscible polymer selected from at least one of the group consisting of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide, and a cross-linking agent comprising at least one water-insoluble salt of multivalent ions capable of interacting with said at least one water miscible polymer;
- spreading a layer of said pre-gel onto a first surface;
- adding a solid support to said pre-gel;
- adding to and blending with the pre-gel at least one trigger compound capable of triggering release of multivalent ions from the cross linking agent into the pre-gel, and
- allowing the pre-gel to cure and adhere to the first surface.
2 more elements
A method of treating a subject comprising:
- spreading a pre-gel onto a tissue of the subject, the pre-gel comprising a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of the group consisting of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide;
- adding a solid support comprising at least one cross linking agent capable of interacting with said at least one water miscible polymer, to said pre-gel;
- allowing said pre-gel to cure and adhere onto the tissue.
A kit, comprising:
- a) a pre-gel comprising at least one phenol-based compound and at least one water miscible polymer selected from at least one of the group consisting of a naturally existing form of a carbohydrate, a synthetically prepared form of a carbohydrate and a salt of an anionic polysaccharide;
- and, separately,
- b) a solid support comprising at least one cross-linking agent capable of interacting with said at least one water miscible polymer upon contact with the pre-gel.
A kit, comprising:
- a) a pre-gel comprising at least one phenol-based compound and at least one water miscible polymer selected from at least one of the group consisting of a naturally existing form of a carbohydrate, a synthetically prepared form of a carbohydrate and a salt of an anionic polysaccharide, and a cross-linking agent comprising at least one water-insoluble salt of multivalent ions capable of interacting with said at least one water miscible polymer;
- and, separately
- b) a solid support;
- and, separately,
- c) at least one trigger compound capable of triggering release of multivalent ions from the cross-linking agent into the pre-gel upon contact with the pre-gel.
2 more elements
Dependencies are inferred from the claim text.