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US 8,709,477 B2Granted
Pharmaceutical dosage form
AssigneeKremers Urban Pharmaceuticals, Inc`
InventorsDirk Kramer, Helene Rey, Mathias Scheer
Life of this patent
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Abstract
This invention relates to a oral pharmaceutical formulation for methylphenidate or its analogs, derivatives, isomers or enantiomers, including d-threo-methylphenidate.
Claims14
A pharmaceutical dosage form exhibiting both immediate release and extend release properties comprising a therapeutically effective amount of active drug selected from methylphenidate and d-threo-methylphenidate comprising:
- a) a tablet core comprising a compressed mixture of coated sugar spheres and a blend of carboxvmethylcellulose, microcrystalline cellulose, magnesium stearate, silicon dioxide, and black iron oxide, said coated sugar spheres comprising
- i. an active drug layer comprising the active drug, hypromellose and talc;
- ii. a sustained release coating comprising ethylcellulose, hydroxypropyl cellulose, triethyl citrate, and talc;
- and
- iii. a controlled release enteric coating comprising hvpromellose acetate succinate;
- and
- b) an immediate release drug coat on said tablet core, said immediate release drug coat comprising active drug, hypromellose, polyethylene glycol, and talc.
4 more elements
Dependencies are inferred from the claim text.