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US 8,709,472 B1Granted
Bioactive agent-loaded heart-targeting nanoparticles
AssigneeAbbott Cardiovascular Systems Inc.
InventorsKatsuyuki Murase, Florian Ludwig, Dariush Davalian
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Abstract
Compositions that contain bioactive agent-loaded nanoparticles with heart targeting capabilities and methods of using the same for the treatment of disease are disclosed.
Claims15
A composition comprising:
- a plurality of nanoparticles;
- a bioactive agent encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles;
- a peptide group comprising a cysteine-arginine-proline-proline-arginine polypeptide, a peptidomimetic thereof or a homolog thereof;
- a lipophilic moiety connected to the peptide group by a poly(ethylene glycol) group, wherein the lipophilic moiety is inserted into the nanoparticle membrane to anchor the peptide group to the nanoparticle;
- and
- a poly(ethylene glycol) group operatively coupled to the surface of the nanoparticle.
3 more elements
Dependencies are inferred from the claim text.