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US 8,709,464 B2Granted
Porous objects having immobilized encapsulated biomolecules
AssigneeThe Regents of the University of Michigan
InventorsPeter X. Ma, Guobao Wei, William V. Giannobile, Qiming Jin
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Abstract
A porous object includes a porous material having internal pore surfaces and external pore surfaces. Releasing material encapsulated biomolecules are immobilized on at least one of the internal pore surfaces, at least one of the external pore surfaces, or combinations thereof.
Claims14
A porous object, comprising:
- a polymer scaffold having nano-fibrous walls, internal pore surfaces and external pore surfaces;
- and
- releasing material encapsulated biomolecules immobilized on at least one of the internal pore surfaces, the external pore surfaces, or combinations thereof;
- wherein the polymer scaffold is, the releasing material is, or both the polymer scaffold and the releasing material are partially dissolved away where the releasing material encapsulated biomolecules are immobilized, the partial dissolving causing the releasing material encapsulated biomolecules to adhere to the polymer scaffold;
- wherein the biomolecules are selected from recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-7, recombinant human platelet-derived growth factor BB, tumor necrosis factor-alpha, hepatocyte growth factor, interleukin-8, angiogenin, angiopoietin-1, and combinations thereof, and wherein the releasing material is selected from poly(lactic-co-glycolic acid) and poly(L-lactic acid).
2 more elements
A method for controlling release of a biomolecule in vivo, the method comprising:
- encapsulating the biomolecule in a releasing material, wherein the biomolecules are selected from recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-7, recombinant human platelet-derived growth factor BB, tumor necrosis factor-alpha, hepatocyte growth factor, interleukin-8, angiogenin, angiopoietin-1, and combinations thereof, and wherein the releasing material is selected from poly(lactic-co-glycolic acid) and poly(L-lactic acid);
- and
- immobilizing a predetermined number of the encapsulated biomolecules on:
- at least one of internal pore surfaces;
- at least one of external pore surfaces;
- or combinations thereof of a polymer scaffold having nano-fibrous walls, wherein immobilizing involves partially dissolving away the polymer scaffold, the releasing material, or both the polymer scaffold and the releasing material, which causes the releasing material encapsulated biomolecules to adhere to the polymer scaffold.
3 more elements
Dependencies are inferred from the claim text.