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US 8,709,463 B2Granted
Hemostatic devices and methods of making same
AssigneeEthicon, Inc.
InventorsDwayne Lee Looney, Kenneth Troger, Bruce Lamb, Benjamin Walthall
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Abstract
The present invention includes compositions suitable for use in a hemostatic device and hemostatic devices utilizing such compositions, as well as methods of making the compositions and the medical devices utilizing such compositions where the compositions contain biocompatible, oxidized cellulose particles having an average designated nominal particle size of about 0.035-4.35 mm and a biocompatible, water-soluble or water-swellable polysaccharide porous binder component.
Claims3
A process for making a composition useful in a hemostatic device, comprising:
- providing a polymer solution having a water-soluble or water-swellable polysaccharide polymer dissolved in a suitable solvent therefore wherein said polymer is sodium carboxymethyl cellulose,
- providing biocompatible, oxidized cellulose particles that comprise carboxylic-oxidized regenerated cellulose and having an average designated nominal size from about of 0.035 to about 4.35 mm,
- contacting said polymer solution with said oxidized cellulose particles under conditions effective to disperse said oxidized cellulose particles homogenously throughout said polymer solution to form a homogenous dispersion,
- subjecting said polymer solution having said particles dispersed throughout to conditions effective to solidify said homogenous dispersion;
- and
- removing said solvent from the solidified dispersion by lyophilization, thereby forming said composition in the form of a porous sponge having a thickness of between 2 mm and 10 mm comprising said particles and a porous, water-soluble or water-swellable polysaccharide polymer binder component.
3 more elements
Dependencies are inferred from the claim text.