Cellulose derivative and hydrogel thereof
AssigneeTeijin Limited
InventorsHiroaki Kaneko, Nobuyuki Endo, Masaya Ito
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Abstract
The invention is a cellulose derivative wherein some of the carboxyl groups of the cellulose derivative carboxymethylcellulose are replaced with —CO—NH—X—CO—Y—Z, and a hydrogel of the same. In the formula, X is a C1-10 divalent hydrocarbon group, Y is a divalent group derived from polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R4, where R4 is a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into prescribed sites with injecting devices such as syringes, and it can thus be utilized as a medical gel or adhesion barrier.
Claims16
A cellulose derivative comprising the chemical structure represented by the following formula (1) as a repeating unit:
- wherein in formula (1), R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b) and (c):
- —H (a)
- —CH2—COOM (b)
- —CH2—CO—NH—X—CO—Y—Z (c)
- where in formula (b), M is hydrogen, an alkali metal or an alkaline earth metal, and
- in formula (c), X is a C1-10 divalent hydrocarbon group, Y is a divalent group derived from polyalkylene oxide with oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R4 (where R4 is a C1-23 hydrocarbon group);
- wherein at least one of R1, R2 and R3 comprises formula (c);
- wherein substituent (c) is present in a degree of substitution of 0.001 to 0.50;
- and
- wherein the cellulose derivative has a weight-average molecular weight of from 1×103 to 5×106.
Dependencies are inferred from the claim text.