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US 8,709,444 B2Granted
Live-attenuated compositions for bacterial infections
AssigneeNorthwestern University
InventorsDavid Klumpp, Anthony Schaeffer, Benjamin Kyle Billips
Life of this patent
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Abstract
The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.
Claims4
A method of treating a urinary tract infection in a subject comprising:
- administering to said subject a live attenuated bacterial composition comprising a strain of uropathogenic E. coli (UPEC) with a mutated or deleted waal gene such that said UPEC are lacking, or are reduced in, O-antigen ligase function,
- wherein said subject is experiencing a urinary tract infection.
Dependencies are inferred from the claim text.