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AssigneeIcahn School of Medicine at Mount Sinai
InventorsAdolfo Garcia-Sastre, Peter Palese
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The present invention relates to recombinant RNA virus templates derived from and applicable to negative strand naturally non-segmented viruses, including the families Bornaviridae, Filoviridae, and Paramyxoviridae, and methods for generating such recombinant RNA virus templates, wherein the templates are generated from two or more recombinant RNA molecules. The invention relates to the use of segmented recombinant RNA virus templates for naturally non-segmented RNA viruses to express heterologous gene products in appropriate host cell systems and/or to construct recombinant viruses taken from that family and that express, package, and/or present the heterologous gene product. The invention includes the expression products and recombinant and chimeric viruses thus prepared and vaccine and therapeutic formulations comprising the recombinant RNA viruses.
A genetically engineered segmented recombinant negative-strand RNA virus of the Paramyxoviridae family of the Mononegavirales order wherein a naturally non-segmented virus having a naturally non-segmented RNA genome is engineered to have a segmented RNA genome comprising two or more distinct viral genomic RNA segments that collectively provide the viral template and encode the required functional transcriptional units of said RNA virus on distinct segmented RNA molecules.
Dependencies are inferred from the claim text.