Clostridium chauvoei polypeptide, DNA encoding the polypeptide and a vaccine comprising the polypeptide
AssigneesIntervet International B.V., UniversitäT Bern
InventorsKeith Redhead, Joachim Frey, Edy M. Vilei, Andreas Walter Claudius Rohwer, Anders Johansson
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Abstract
The present invention pertains to the identification and initial characterization of CctA, a novel, secreted toxin of Clostridium chauvoei that represents the major cytotoxic activity of C. chauvoei. This toxin confers C. chauvoei its characteristic strong hemolytic activity towards erythrocytes of various species, since anti-CctA antibodies fully neutralize hemolysis by C. chauvoei on standard blood-agar medium or in cell-free supernatants of liquid cultures.
Claims5
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO 1 that is expressed recombinantly.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO 1.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO 1.
Dependencies are inferred from the claim text.