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AssigneeBiomay AG
InventorsRaffaela Campana, Rudolf Valenta, Susanne Vrtala, Ines Swoboda, Margarete Focke-Tejkl, Anna Gieras, Susanne Spitzauer, Peter Valent, Katharina Blatt, Birgit Linhart, Dietrich Kraft
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Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.
A hypoallergenic mosaic antigen assembled from all of the amino acids comprising a naturally-occurring allergen, though rearranged into a different order, wherein said mosaic allergen is designed to retain at least one T-cell epitope specific to said naturally-occurring allergen and is capable of inducing IgG antibodies that hinder IgE binding to said naturally-occurring allergen, wherein said naturally-occurring allergen is the major birch pollen allergen Bet v 1 and the amino acid sequence of said mosaic antigen comprises SEQ ID NO:
Dependencies are inferred from the claim text.