Compositions for inhibiting NADPH oxidase activity
AssigneePCB Associates, Inc.
InventorsMark Fredrick McCarty, Sheldon Saul Hendler, David Michael Rorvik, Toyoshi Inoguchi
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Abstract
Phycobilins are disclosed to have prodrug activity as inhibitors of NADPH oxidase activity and are disclosed to be useful in the prophylaxis and/or treatment of medical conditions associated with or linked to an NADPH oxidase activity. Compositions containing phycobilins are described which facilitate the administration of phycobilins.
Claims30
A phycochemical composition for administration to a mammalian subject, phycochemical composition having a prodrug activity for inhibiting NADPH oxidase activity, the phycochemical composition comprising:
- an isolated phycobilin dissolved or suspended within a pharmaceutically acceptable carrier and
- a capsule having a gelatinous case for containing said isolated phycobilin,
- said isolated phycobilin being converted to a phycorubin when administered to said mammalian subject for inhibiting NADPH oxidase activity,
- said isolated phycobilin being selected from the group consisting of phycocyanobilin, phycoerythrobilin, and phytochromobilin, said phycobilin including a peptide fragment of a phycocyanin conjugated thereto to form a peptide conjugated phycobilin, the peptide fragment being 100 amino acids in length or less, the peptide conjugated phycobilin being substantially purified.
A phycochemical composition for administration to a mammalian subject, the phycochemical composition having a prodrug activity for inhibiting NADPH oxidase activity, the phycochemical composition comprising:
- an isolated phycobilin admixed with a pharmaceutically acceptable carrier material or a food grade filler and compressed into a tablet, said isolated phycobilin being converted to a phycorubin when administered to said mammalian subject for inhibiting NADPH oxidase activity,
- said isolated phycobilin being selected from the group consisting of phycocyanobilin, phycoerythrobilin, phytochromobilin, said phycobilin including a peptide fragment of a phycocyanin conjugated thereto to form a peptide conjugated phycobilin, the peptide fragment being 100 amino acids in length or less, the peptide conjugated phycobilin being substantially purified.
A phycochemical composition for intravenous administration or administration by injection to a mammalian subject, the phycochemical composition having a prodrug activity for inhibiting NADPH oxidase activity, the phycochemical composition comprising:
- an isolated phycobilin dissolved or suspended within a physiologically acceptable sterile solution suitable for injection, said isolated phycobilin being converted to a phycorubin when administered to said mammalian subject for inhibiting NADPH oxidase activity,
- said isolated phycobilin being selected from the group consisting of phycocyanobilin, phycoerythrobilin, phytochromobilin, said phycobilin including a peptide fragment of a phycocyanin conjugated thereto to form a peptide conjugated phycobilin, the peptide fragment being 100 amino acids in length or less, the peptide conjugated phycobilin being substantially purified.
A phycochemical composition for topical administration to a mammalian subject, the phycochemical composition having a prodrug activity for inhibiting NADPH oxidase activity, the phycochemical composition comprising:
- an isolated phycobilin dissolved or suspended within a dermatologically acceptable emollient carrier, said isolated phycobilin being converted to a phycorubin when topically administered to said mammalian subject for inhibiting NADPH oxidase activity,
- said isolated phycobilin being selected from the group consisting of phycocyanobilin, phycoerythrobilin, phytochromobilin, each said phycobilin including a peptide fragment of a phycocyanin conjugated thereto to form a peptide conjugated phycobilin, the peptide fragment being 100 amino acids in length or less, the peptide conjugated phycobilin being substantially purified.
A nutraceutical composition comprising a nutrient substance admixed with a phycochemical composition comprising an isolated phycobilin,
- said isolated phycobilin being selected from the group consisting of phycocyanobilin, phycoerythrobilin, phytochromobilin, said phycobilin including a peptide fragment of a phycocyanin conjugated thereto to form a peptide conjugated phycobilin, the peptide fragment being 100 amino acids in length or less, the peptide conjugated phycobilin being substantially purified.
A cosmeceutical composition comprising a cosmetic substance admixed with a phycochemical composition comprising an isolated phycobilin,
- said isolated phycobilin being selected from the group consisting of phycocyanobilin, phycoerythrobilin, phytochromobilin, said phycobilin including a peptide fragment of a phycocyanin conjugated thereto to form a peptide conjugated phycobilin, the peptide fragment being 100 amino acids in length or less, the peptide conjugated phycobilin being substantially purified.
A method for prophylaxis or treatment of a subject for a medical condition associated with or linked to an NADPH oxidase activity, the method comprising the step of administering one or more isolated phycobilins to a subject in a prophylactically or therapeutically effective amount for prophylaxis or treatment of a medical condition associated with or linked to an NADPH oxidase activity,
- said isolated phycobilin being selected from the group consisting of phycocyanobilin, phycoerythrobilin, phytochromobilin, said phycobilin including a peptide fragment of a phycocyanin conjugated thereto to form a peptide conjugated phycobilin, the peptide fragment being 100 amino acids in length or less, the peptide conjugated phycobilin being substantially purified.
Dependencies are inferred from the claim text.