Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirusi in hexameric form
AssigneeInstitut Pasteur
InventorsMarie Flamand, Françoise Megret, Sophie Alcon, Antoine Talarmin, Philippe Despres, Vincent Deubel
Life of this patent
Estimating the term…
Abstract
The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
Claims8
Monoclonal antibodies with affinity for hexameric NS1 protein of a flavivirus or purified polyclonal antibodies with affinity for hexameric NS1 protein of a flavivirus, wherein the NS1 protein is the NS1 protein of a dengue virus, and wherein the antibody has high affinity for the hexameric NS1 protein.
Dependencies are inferred from the claim text.