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US 8,709,425 B2Granted
Antibodies to non-functional P2X7 receptor
AssigneeBiosceptre International Limited
InventorsJulia Alexander Barden, Angus Gidley-Baird
Life of this patent
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Abstract
The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between function and non-functional P2X7 receptors, pharmaceutical compositions and kits containing the antibodies, and methods of using the antibodies for the detection, diagnosis and treatment of disease conditions.
Claims8
An isolated antibody that binds to an extracellular domain of a P2X7 receptor, said P2X7 receptor having the amino acid sequence shown in SEQ ID NO:
- 1, wherein the receptor has an impaired response to ATP such that it is unable to form an apoptotic pore under normal physiological conditions, and wherein the antibody does not bind to an extracellular domain of a P2X7 receptor having an amino acid sequence as shown in SEQ ID NO:
- 1 wherein the receptor does not have an impaired response to ATP.
Dependencies are inferred from the claim text.