Pharmaceutical composition for treating CAPRIN-1 expressing cancer
AssigneeToray Industries, Inc.
InventorsFumiyoshi Okano, Takanori Saito
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Abstract
According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody comprising a heavy chain variable region that comprises SEQ ID NOS: 39, 40, and 41 and a light chain variable region that comprises SEQ ID NOS: 43, 44, and 45 or a fragment thereof as an active ingredient and having immunological reactivity with a CAPRIN-1 protein.
Claims14
A pharmaceutical composition for the treatment of a CAPRIN-1-expressing cancer or preventing the recurrence of a CAPRIN-1-expressing cancer, comprising an antibody or a fragment thereof as an active ingredient that has immunological reactivity with a CAPRIN-1 protein, wherein the antibody comprises a heavy chain variable region comprising SEQ ID NOS:
- 39, 40, and 41 and a light chain variable region comprising SEQ ID NOS:
- 43, 44, and 45 or a fragment thereof having anti-tumor activity.
An antibody, which comprises a heavy chain variable region comprising SEQ ID NOS:
- 39, 40, and 41 and a light chain variable region comprising SEQ ID NOS:
- 43, 44, and 45, and has immunological reactivity with a CAPRIN-1 protein.
The method for treating a cancer in a subject with cancer according to claim. 8, wherein the pharmaceutical compositions comprising, the pharmaceutical combination is administered intraperitoneally.
Dependencies are inferred from the claim text.