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US 8,709,404 B2Granted
Immunotherapy in cancer treatment
AssigneeSentoClone International AB
InventorsOla Winqvist, Magnus Thörn
Life of this patent
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Abstract
The present invention relates to a novel method of cancer immuno-therapy and to a kit for use in this method. Specifically, the present invention relates to a novel method of collecting lymphocytes from sentinel lumph nodes and in vitro culture for the multiplication thereof lymphocytes.
Claims14
A method for treating cancer having a primary tumor in a human patient, comprising
- (a) providing lymphocytes obtained from sentinel lymph nodes from the patient, wherein the sentinel lymph nodes are the first lymph nodes in the lymphatic system that receive lymphatic drainage from the primary tumor area;
- (b) expanding the lymphocytes in vitro, wherein the lymphocytes are stimulated in vitro by addition of a stimulating agent selected from the group consisting of IL-2, IL-12, anti-CD3 antibody, and anti-CD28 antibody and are exposed to recombinant tumor antigen and/or autologous tumor extract, optionally presented with antigen presenting cells selected from B-cells, macrophages, monocytes, dendritic cells, or Langerhans cells;
- and
- (c) transferring the expanded lymphocytes into the patient.
1 more element
Dependencies are inferred from the claim text.