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US 8,709,400 B2Granted
Inducement of organogenetic tolerance for pancreatic xenotransplant
AssigneeWashington University
InventorMarc Hammerman
Life of this patent
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Abstract
Provided herein is an approach to establish organogenetic tolerance via prior transplantation of pig embryonic pancreas, thereby enabling subsequent implantation of porcine islets in a subject without the need for immune-suppression. In one aspect of the invention, porcine pancreatic primordia are implanted into a mammalian subject, and after a period of time sufficient to induce tolerance, porcine islet cells are implanted in the subject.
Claims22
A method for treating diabetes mellitus in a subject in need thereof comprising:
- implanting a porcine pancreatic primordium, or a portion thereof, in an amount effective to induce tolerance to porcine islet cells comprising mature antigen-presenting cells, into a non-porcine mammalian subject;
- waiting a period of time sufficient to induce tolerance to porcine islet cells comprising mature antigen-presenting cells;
- and
- implanting porcine islet cells comprising mature antigen-presenting cells into the non-porcine mammalian subject.
1 more element
Dependencies are inferred from the claim text.