Therapeutic vitamin D sun-protecting formulations and methods for their use
AssigneeAvidas Pharmaceuticals LLC
InventorsMargaret M. Gardner, Charles L. Pamplin, III
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Abstract
The present invention concerns topical sun-protecting formulations including therapeutically effective amounts of Vitamin D, including formulations that provide Vitamin D in bioavailable amounts that correspond to decreased natural Vitamin D production resulting from the sun-blocking effects of the formulations and formulations for the prevention and treatment of disorders and disease states associated with vitamin D deficiency and vitamin D insufficiency.
Claims24
A therapeutic sun-protecting composition, comprising:
- (a) at least one sun-protecting agent;
- (b) at least one physiologic biological vitamin D compound said physiologic biological vitamin D compound being present in a therapeutically effective amount such that, upon topical administration to a mammal, said physiologic biological vitamin D compound is absorbed through the skin of said mammal and causes a measurable increase in said mammal's serum physiologic biological vitamin D levels in the absence of an alcohol carrier;
- and (c) a pharmaceutical carrier effective for topical administration of said at least one sun-protecting agent and said at least one physiologic biological vitamin D compound, wherein said physiologic biological vitamin D compound is separated from said sun-protecting agent within said therapeutic sun-protecting composition.
A therapeutic sun-protecting formulation prepared by a process comprising the steps of:
- (a) providing a therapeutically effective amount of a physiologic biological vitamin D compound:
- (b) providing a pharmaceutical carrier effective for topical administration of said physiologic biological vitamin D compound, said pharmaceutical carrier being capable of delivering said physiologic biological vitamin D compound to a mammal to cause a measurable increase in said mammal's serum vitamin D levels while decreasing the exposure of said mammal's skin to UV radiation, wherein said pharmaceutical carrier is capable of delivering said physiologic biological vitamin D compound to cause a measurable increase in said mammal's serum vitamin D levels in the absence of alcohol;
- and (c) mixing said physiologic biological vitamin D compound and said pharmaceutical carrier.
A therapeutic sun-protecting composition, comprising:
- (a) at least one sun-protecting agent capable of absorbing ultraviolet radiation;
- (b) at least one therapeutic physiologic biological vitamin D compound;
- and (c) a pharmaceutical carrier, wherein, upon topical administration of said therapeutic sun-protecting composition to a mammal, said pharmaceutical carrier simultaneously delivers (i) said therapeutic physiologic biological vitamin D compound through the skin and into the bloodstream of said mammal to cause a measurable increase in said mammal's serum vitamin D levels in the absence of an alcohol carrier;
- and (ii) said sun-protecting agent to the surface of the skin of said mammal.
Dependencies are inferred from the claim text.