Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses

A pharmaceutical or cosmetic foamable composition for application to a delivery site in a subject, the composition comprising:

• A. a carrier comprising:
• a. about 5% to about 20% by weight of the carrier of at least two poloxamers;
• b. water;
• c. about 0.2% to about 15% by weight of the carrier of at least one hydrophobic solvent;
• d. about 0.5% to about 5% by weight of the carrier of at least one surfactant;
• e. about 0.5% to about 15% by weight of the carrier of at least one hydrophilic solvent;
• f. one or more active agents, which optionally may be encapsulated;
• and
• B. a propellant,
• wherein the composition is stored in an aerosol container and upon release expands to form a breakable short term stable foam;
• wherein the weight ratio of the carrier to the propellant is about 100:5 to about 100:25;
• wherein the at least two poloxamers are a synergistic combination of at least one liquid poloxamer and at least one solid poloxamer;
• and
• wherein the one or more active agents are soluble in the composition.

A pharmaceutical or cosmetic composition comprising either:

• A.
• a. water;
• b. at least two poloxamers at a concentration of about 0.1% to about 15% by weight of the composition:
• B.
• a. about 5% to about 20% by weight of the composition of at least two poloxamers;
• b. about 79% to about 93.8% of the composition of water;
• c. about 0.2% to about 15% by weight of the composition of at least one hydrophobic solvent;
• d. about 0.5% to about 5% by weight of the composition of at least one surfactant;
• and
• e. about 0.5% to about 15% by weight of the composition of at least one hydrophilic solvent;
• or
• C.
• a. about 1% to about 20% by weight of the composition of at least two poloxamers;
• b. 0% to about 5% by weight of the composition of at least one polymeric agent;
• c. about 79% to about 99% of the composition of water;
• d. 0% to about 5% by weight of the composition of at least one silicone;
• and
• e. 0% to about 5% by weight of the composition of at least one surfactant;
• wherein A, B or C are pressurized with a liquefied or compressed propellant;
• wherein the weight ratio of the composition to the propellant is about 100:5 to about 100:25;
• and
• wherein the at least two poloxamers are a synergistic combination of at least one liquid poloxamer and at least one solid poloxamer.