Methods of making a diagnostic device by interweaving hydrophobic and hydrophilic fibers, and diagnostic device therefrom

A diagnostic device made by a method comprising:

• providing at least one strand of a diagnostic-fiber composition, wherein the diagnostic-fiber composition comprises degummed silk immobilized with at least one of a first reagent, a second reagent or both,
• providing at least one strand of a hydrophobic-fiber composition, and
• inter-weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition, wherein the inter-weaving between the strands is configured to result in an angle between the strands which provides greater control to affect flow properties of the at least one strand of the diagnostic-fiber composition wherein the strand of the diagnostic-fiber composition and the strand of the hydrophobic-fiber composition are wound relative to one another.

A diagnostic device comprising:

• at least one strand of a diagnostic-fiber composition, wherein the diagnostic-fiber composition comprises degummed silk immobilized with at least one of a first reagent, a second reagent or both;
• and
• at least one strand of a hydrophobic-fiber composition that is inter-woven with the at least one strand of diagnostic-fiber composition, wherein inter-weaving between the strands is configured to result in an angle between the strands which provides greater control to affect flow properties of the at least one strand of the diagnostic-fiber composition wherein the strand of the diagnostic-fiber composition and the strand of the hydrophobic-fiber composition are wound relative to one another.