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US 8,709,310 B2Granted
Spray drying vancomycin
AssigneeHospira, Inc.
InventorsCynthia Fragale, Daniel Brueck
Life of this patent
Estimating the term…
Abstract
A method and formulation for preparing spray dried vancomycin. In various embodiment, the formulation includes vancomycin HC1 (10-20%) and one or more of the following PEG (0-5%), mannitol (0-5%), ethanol (0-10%), and a citrate buffer. Spray dried vancomycin has favorable reconstitution times and water content.
Claims18
A method for preparing a powdered vancomycin pharmaceutical formulation for injection, the method comprising:
- providing a solution comprising vancomycin HCl, mannitol and polyethylene glycol (PEG);
- and
- spray drying the solution to form a powder that can be reconstituted and administered by IV infusion.
A method for reducing the loss of vancomycin in a spray-drying process, the method comprising:
- combining vancomycin, mannitol and polyethylene glycol (PEG) in an aqueous solution, spray drying the solution to form a powder that can be reconstituted and administered to a patient.
A method for reducing the loss of vancomycin in a spray-drying process, comprising:
- combining vancomycin and a citrate buffer in an aqueous solution;
- and
- spray-drying the solution to form a powder that can be reconstituted and administered to a patient.
Dependencies are inferred from the claim text.