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US 8,709,076 B1Granted
Two-piece prosthetic valve
AssigneeCorMatrix Cardiovascular, Inc.
InventorsRobert Matheny, Zachary Reinhardt
Life of this patent
Estimating the term…
Abstract
A two-piece prosthetic valve having first and second members, a first end of the first member being sized and configured to receive a second end of the second member therein, the second end of the second member being attached to the first member at at least one commissure connection point to form at least one leaflet therein.
Claims19
A two-piece prosthetic valve assembly, consisting of:
- a bioremodelable first conduit member having first and second ends, and an internal lumen, said first conduit member lumen having an inner surface;
- and
- a separate bioremodelable second conduit member having first and second ends, and an internal lumen,
- said first and second conduit members comprising an extracellular matrix (ECM) material from a mammalian tissue source, said tissue source comprising small intestine submucosa (SIS),
- said first end of said first conduit member being configured to receive said second end of said second conduit member therein, wherein said second end of said second conduit member is disposed in said first end of said first conduit member, said second end of said second conduit member being directly attached to said first conduit member lumen inner surface at a first commissure connection point, wherein said first conduit member lumen and said second conduit member lumen are in communication, and wherein a first valve leaflet is formed by said second end of said second conduit member within said first conduit member lumen, said first valve leaflet being configured to selectively restrict fluid flow through said two-piece valve assembly, and
- wherein, following attachment of said valve assembly to a cardiovascular vessel, said first and second conduit members are remodeled by cardiovascular tissue to form an integral valve member comprising remodeled cardiovascular tissue.
3 more elements
A two-piece prosthetic valve assembly, consisting of:
- a bioremodelable first conduit member having first and second ends, and an internal lumen, said first conduit member lumen having an inner surface;
- and
- a separate bioremodelable second conduit member having first and second ends, and an internal lumen,
- said first and second conduit members comprising an extracellular matrix (ECM) material from a mammalian tissue source, said tissue source comprising small intestine submucosa (SIS), said SIS further comprising an exogenously added pharmacological agent, said pharmacological agent comprising a statin selected from the group consisting of atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin,
- said first end of said first conduit member being configured to receive said second end of said second conduit member therein, wherein said second end of said second conduit member is disposed in said first end of said first conduit member, said second end of said second conduit member being directly attached to said first conduit member lumen inner surface at a first commissure connection point, wherein said first conduit member lumen and said second conduit member lumen are in communication, and wherein a first valve leaflet is formed by said second end of said second conduit member within said first conduit member lumen, said first valve leaflet being configured to selectively restrict fluid flow through said two-piece valve assembly, and
- wherein, following attachment of said valve assembly to a cardiovascular vessel, said first and second conduit members are remodeled by cardiovascular tissue to form an integral valve member comprising remodeled cardiovascular tissue.
3 more elements
Dependencies are inferred from the claim text.