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US 8,709,072 B2Granted
Endoprosthesis
AssigneeBoston Scientific Scimed, Inc.
InventorsMourad Rahi, Liliana Atanasoska, Rajesh Radhakrishnan, Robert W. Warner, Barry Cool
Life of this patent
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Abstract
A stent includes a MOF which adjusts pore size upon desorption or adsorption of organic molecules.
Claims23
A stent comprising:
- a tubular body comprising a substrate and a coating on the substrate,
- the coating comprising a first layer of coating and a second layer of coating different from the first layer, the first layer of coating comprising a first metal-organic framework (MOF), which adjusts pore size upon desorption or adsorption of organic molecules, and a first therapeutic agent stored in the first MOF, the second layer of coating comprising a second MOF and a second therapeutic agent stored in the second MOF, the first MOF being different from the second MOF or the first therapeutic agent being different from the second therapeutic agent, and the first and second therapeutic agents to be released with different release profiles.
A method comprising:
- forming a tubular body comprising a substrate, and
- forming a coating on the substrate, wherein forming the coating comprises:
- forming a first layer of the coating comprising a first metal-organic framework (MOF) that provides a high hydrogen bonding energy and that adjusts pore size upon desorption or adsorption of organic molecules;
- loading the first MOF with a first therapeutic agent;
- forming a second layer of the coating comprising a second MOF, the second layer being different from the first layer;
- and
- loading the second MOF with a second therapeutic agent, the first MOF being different from the second MOF or the first therapeutic agent being different from the second therapeutic agent, and the first and second therapeutic agents to be released with different release profiles.
4 more elements
Dependencies are inferred from the claim text.