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US 8,709,071 B1Granted
Stent with preferential coating
AssigneeAbbott Cardiovascular Systems Inc.
InventorsBin Huang, David C. Gale, Daniel A. Castro, Vincent J. Gueriguian
Life of this patent
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Abstract
This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.
Claims7
A stent comprising:
- a stent body comprising a plurality of structural elements, each structural element comprising a luminal surface, an abluminal surface and a sidewall surface connecting the luminal surface to the abluminal surface, wherein the stent body is made of a bioabsorbable material which allows the stent body upon implantation to disintegrate, absorb and disappear from a region of implantation;
- a prohealing coating above and in contact with the luminal surface and the abluminal surface of the stent body, the prohealing coating comprising a prohealing agent that promotes cell growth;
- and
- an antiproliferative coating above and in contact with the prohealing coating that is above the abluminal surface of the stent body, the antiproliferative coating comprising an antiproliferative active agent,
- wherein the luminal surface of the stent body is free or substantially free of antiproliferative coating.
2 more elements
A stent comprising:
- a stent body comprising a plurality of structural elements, each structural element comprising a luminal surface, an abluminal surface and a sidewall surface connecting the luminal surface to the abluminal surface, wherein the stent body is made of a bioabsorbable material which allows the stent body upon implantation to disintegrate, absorb and disappear from a region of implantation;
- a prohealing coating above and in contact with the luminal surface and the abluminal surface of the stent body, the prohealing coating comprising a prohealing agent that promotes cell growth;
- and
- an antiproliferative coating above and in contact with the prohealing coating that is above the abluminal surface of the stent body, the antiproliferative coating comprising an antiproliferative active agent,
- wherein the prohealing agent is selected from the group consisting of a junction membrane protein vascular endothelial (VE)-cadherin, the active fragment of osteopontin, the antibody CD-133, and any combination thereof.
2 more elements
Dependencies are inferred from the claim text.