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US 8,709,023 B2Granted
Absorbable / biodegradable composite yarn constructs and applications thereof
AssigneePoly-Med, Inc.
InventorsShalaby W. Shalaby, Shawn Peniston, Scott Taylor, Douglas D. Greene
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Abstract
Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
Claims17
A warp-knitted composite mesh having a minimum area density of 50 g/m2, the mesh comprising:
- a slow-absorbing, biodegradable multifilament yarn component having an individual filament diameter of less than about 20 microns, the slow-absorbing yarn component comprising a segmented copolymer comprising at least 80 percent of l-lactide-based sequences;
- and
- a fast-absorbing multifilament yarn component having an individual filament diameter of greater than 20 microns, the fast-absorbing yarn component comprising a segmented polyaxial copolymer comprising at least 70 percent of glycolide-based sequences;
- wherein the composite mesh is knit in a four bar pattern wherein the slow-absorbing yarn component is knit in a two bar pattern and the fast-absorbing yarn component is knit in a two bar pattern and are initially mechanically interdependent, and wherein upon incubation in a buffered solution at a pH of 7.2 at about 50° C. for about 2 weeks the composite mesh retains more than 20 percent of its maximum burst force and undergoes at least 12 percent elongation under a force of 16 N per cm of mesh width.
1 more element
Dependencies are inferred from the claim text.