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US 8,708,996 B2Granted
Methods and device for synergistic mitigation of reperfusion injury after an ischemic event
AssigneeAbbott Cardiovascular Systems Inc.
InventorsPaul Consigny, Kevin J. Ehrenreich, Jesus Magana, Syed Hossainy
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Abstract
A method for synergistic mitigation of reperfusion injury after an ischemia event in a subject.
Claims17
A method for mitigating reperfusion injury to a tissue in a subject suffering from an ischemic event in a blood vessel, the method comprising:
- locally administering a calpain inhibitor to an ischemic blood vessel during a cycle of inflation and deflation of a balloon within the ischemic blood vessel during a postconditioning procedure,
- wherein the calpain inhibitor is locally administered to an area of the blood vessel distal to a lesion.
A method for mitigating reperfusion injury to a tissue of a mammal, the method comprising:
- sequentially reducing perfusion to the tissue by inflating a balloon within an ischemic blood vessel for a first period of time, and allowing perfusion of the tissue by deflating the balloon within the ischemic blood vessel for a second period of time, and
- locally administering a beneficial agent selected from the group consisting of endothelin receptor blockers, pH stabilizing agents, and calpain inhibitors during postconditioning to a subject, wherein the beneficial agent enhances mitigation of reperfusion injury to an organ or tissue distal to an ischemia,
- wherein the beneficial agent is in a vehicle having a biomaterial.
A method for mitigating tissue infarction after an ischemic event, the method comprising:
- introducing a balloon catheter into an ischemic blood vessel, the balloon catheter having a compliant balloon;
- engaging an actuator in one motion to inflate the balloon within the ischemic blood vessel to occlude the blood flow therethrough for a first period of time;
- disengaging the actuator in one motion to deflate the balloon within the blood vessel to permit at least partial reperfusion of blood flow through the blood vessel for a second period of time;
- alternating the engaging and disengaging steps to alternate the inflation and deflation rounds for at least two cycles to achieve postconditioning of the ischemic blood vessel;
- and
- sequentially administering a beneficial agent locally to the blood vessel during either inflation or deflation of the balloon, wherein the infarcted tissue exhibits a four-fold increase in uptake of the beneficial agent as compared to uptake at healthy tissue.
3 more elements
Dependencies are inferred from the claim text.