Injector and dual-chamber system having sterile components
AssigneeLTS Lohmann Therapie-Systeme AG
InventorRudolf Matusch
Life of this patent
Estimating the term…
Abstract
The invention relates to a single-use injector (4) and a dual-chamber system (99), wherein at least one first chamber (105) is part of a cylinder-piston unit (100) that can be received in the single-use injector, and wherein the second chamber (255) is part of a container (250) that can be at least temporarily closed by means of a stopper (257) and that is inserted in a container adapter (200) releaseably supported on the single-use injector. To this end, the plug comprises a plug hole. The container adapter comprises a transfer tube that is closed at first. When the container is inserted in the container adapter, the transfer tube (242) connects the interior of the cylinder-piston unit to the interior of the container.
Claims5
In combination with a single-use injector (4) and two-chamber system (99), including a housing (10), a cylinder/piston unit (100) operably retained by the housing (10) and comprising a cylinder (101) having a cylinder interior (110) initially filled with water (1) for injection purposes or subsequently filled with an injection solution (3) and having a first chamber (105), a piston (111) in operable arrangement in the rear of the cylinder (101), a spring-activated piston actuating plunger (60) operably arranged in the housing (10) in mechanical communication with the piston (111), the cylinder (101) including a floor having a nozzle-like hole (106) passing therethrough for needless injection, the piston actuating plunger (60) housed within the housing (10), a detachable container (250) having an inoperative or an operative position, the detachable container (250) when in the operative position in connective arrangement with but separated from and mounted outside of the housing (10) and when in the inoperative condition the detachable container (250) is detached from the housing (10), the detachable container (250) having a second chamber (255) having an interior (252) initially filled with an active substance (2), the detachable container (250) includes a stopper (257), the detachable container (250) closed at least temporarily by the stopper (257), a detachable container adapter (200) having an inoperative or an operative position, the detachable container adapter (200) when in the operative position detachably mounted between the housing (10) and the detachable container (250) and when in the inoperative position the detachable container adapter (200) is detached from both the housing (10) and the detachable container (250), the detachable container (250) in partial insertable relationship with the detachable container adapter (200) with the second chamber (255) positioned substantially outside of the detachable container adapter (200), the improvement which comprises:
- the stopper (257) has a stopper hole (254) passing therethrough,
- the detachable container adapter (200) includes an initially closed transfer tube (242),
- the detachable container (250), upon insertion of the detachable container (250) in a container insertion direction (7) into operative engagement with the detachable container adapter (200), the transfer tube (242) passes through stopper hole (254) and connects in fluid communication the cylinder interior (110) of the cylinder/piston unit (100) to the interior (252) of the detachable container (250), and
- means for causing the water (1) which initially filled the cylinder interior (110) to be removed from the cylinder interior (110) and transferred to the detachable container (250) upon the transfer tube (242) passing through the stopper hole (254) and for mixing the transferred water (1) with the active substance (2) for forming an injection solution (3) to be re-transferred to the cylinder interior (110) prior to use of the injector (4),
- the transfer tube (242) is initially closed by means of a membrane cap (290) including a first non-liquid membrane (292),
- the stopper hole (254) is initially closed by means of a second non-liquid membrane (256), and
- the transfer tube (242) is initially closed by means of the membrane cap (290) including the first non-liquid membrane (292), the first non-liquid membrane (292) and the second non-liquid membrane (256) are in initial abutting contacting relationship with each other prior to insertion of the detachable container (250), when the detachable container (250) is inserted into the detachable container adapter (200), the transfer tube (242) pierces the first non-liquid membrane (256) and then the second non-liquid membrane (292).
In combination with a single-use injector (4) and two-chamber system (99), including a housing (10), a cylinder/piston unit (100) operably retained by the housing (10) and comprising a cylinder (101) having a cylinder interior (110) initially filled with water (1) for injection purposes or subsequently filled with an injection solution (3) and having a first chamber (105), a piston (111) in operable arrangement in the rear of the cylinder (101), a spring-activated piston actuating plunger (60) operably arranged in the housing (10) in mechanical communication with the piston (111), the cylinder (101) including a floor having a nozzle-like hole (106) passing therethrough for needless injection, the piston actuating plunger (60) housed within the housing (10), a detachable container (250) having an inoperative or an operative position, the detachable container (250) when in the operative position in connective arrangement with but separated from and mounted outside of the housing (10) and when in the inoperative condition the detachable container (250) is detached from the housing (10), the detachable container (250) having a second chamber (255) having an interior (252) initially filled with an active substance (2), the detachable container (250) includes a stopper (257), the detachable container (250) closed at least temporarily by the stopper (257), a detachable container adapter (200) having an inoperative or an operative position, the detachable container adapter (200) when in the operative position detachably mounted between the housing (10) and the detachable container (250) and when in the inoperative position the detachable container adapter (200) is detached from both the housing (10) and the detachable container (250), the detachable container (250) in partial insertable relationship with the detachable container adapter (200) with the second chamber (255) positioned substantially outside of the detachable container adapter (200), the improvement which comprises:
- the stopper (257) has a stopper hole (254) passing therethrough,
- the detachable container adapter (200) includes an initially closed transfer tube (242),
- the detachable container (250), upon insertion of the detachable container (250) in a container insertion direction (7) into operative engagement with the detachable container adapter (200), the transfer tube (242) passes through stopper hole (254) and connects in fluid communication the cylinder interior (110) of the cylinder/piston unit (100) to the interior (252) of the detachable container (250),
- means for causing the water (1) which initially filled the cylinder interior (110) to be removed from the cylinder interior (110) and transferred to the detachable container (250) upon the transfer tube (242) passing through the stopper hole (254) and for mixing the transferred water (1) with the active substance (2) for forming an injection solution (3) to be re-transferred to the cylinder interior (110) prior to use of the injector (4), and
- the transfer tube (242) comprises a closed tip (243), the transfer tube (242) has a longitudinal transfer tube hole (244) opening into a transverse hole (245) penetrating the transfer tube (242) proximate the closed tip (243), a membrane cap (290) having an elastically deformable wall region (291) and including a first membrane (292), the tip (243) is pointed and housed within the membrane cap prior to insertion into the detachable container (250) with the transverse hole (245) in sealed relationship with the wall region (291), a second membrane (256) is in initial closing relationship with the stopper hole (254), upon insertion the tip (243) pierces the first non-liquid membrane (292) and the second membrane (256) and passes through stopper hole (254).
In combination with a single-use injector (4) and two-chamber system (99), including a housing (10), a cylinder/piston unit (100) operably retained by the housing (10) and comprising a cylinder (101) having a cylinder interior (110) initially filled with water (1) for injection purposes or subsequently filled with an injection solution (3) and having a first chamber (105), a piston (111) in operable arrangement in the rear of the cylinder (101), a spring-activated piston actuating plunger (60) operably arranged in the housing (10) in mechanical communication with the piston (111), the cylinder (101) including a floor having a nozzle-like hole (106) passing therethrough for needless injection, the piston actuating plunger (60) housed within the housing (10), a detachable container (250) having an inoperative or an operative position, the detachable container (250) when in the operative position in connective arrangement with but separated from and mounted outside of the housing (10) and when in the inoperative condition the detachable container (250) is detached from the housing (10), the detachable container (250) having a second chamber (255) having an interior (252) initially filled with an active substance (2), the detachable container (250) includes a stopper (257), the detachable container (250) closed at least temporarily by the stopper (257), a detachable container adapter (200) having an inoperative or an operative position, the detachable container adapter (200) when in the operative position detachably mounted between the housing (10) and the detachable container (250) and when in the inoperative position the detachable container adapter (200) is detached from both the housing (10) and the detachable container (250), the detachable container (250) in partial insertable relationship with the detachable container adapter (200) with the second chamber (255) positioned substantially outside of the detachable container adapter (200), the improvement which comprises:
- the stopper (257) has a stopper hole (254) passing therethrough,
- the detachable container adapter (200) includes an initially closed transfer tube (242),
- the detachable container (250), upon insertion of the detachable container (250) in a container insertion direction (7) into operative engagement with the detachable container adapter (200), the transfer tube (242) passes through stopper hole (254) and connects in fluid communication the cylinder interior (110) of the cylinder/piston unit (100) to the interior (252) of the detachable container (250),
- means for causing the water (1) which initially filled the cylinder interior (110) to be removed from the cylinder interior (110) and transferred to the detachable container (250) upon the transfer tube (242) passing through the stopper hole (254) and for mixing the transferred water (1) with the active substance (2) for forming an injection solution (3) to be re-transferred to the cylinder interior (110) prior to use of the injector (4), and
- the detachable container (250) is a second cylinder/piston unit (250).
Dependencies are inferred from the claim text.