US 8,708,907 B2Granted

Method and apparatus for determining one or more blood parameters from analog electrical signals

AssigneeElfi-Tech Ltd.

InventorsIlya Fine, Alexander Kaminsky

Life of this patent

Estimating the term…

Abstract

Embodiments of the present invention relate to a system and method for in vivo measurement of blood parameters by processing analog electrical signals from a plurality of photodetectors. In some embodiments, it is possible to determine one or more blood parameters according to (i) a first electrical signal from a first detector and (ii) a second electrical signal from a second photodetector. A difference analog electrical signal is generated, indicative of a difference between the light response signal at the first location and light response signal at the second location, is generated. One or more blood parameters may be detected according to the difference analog electrical signal.

Claims12

Dependent claims

A method for obtaining physiological information from a subject in accordance with a light field whose intensity varies according to location, the method comprising:

a) applying partially or entirely coherent light to a target region of the subject to induce a light response signal from the illuminated target region which contributes to a location-dependent light field LF(x, y, z);
b) detecting the light field LF(x1, y1, z1) prevailing at a first location (x1, y1, z1) to generate a first analog electrical signal A1(t), the first analog electrical signal A1(t) including a dynamic light scattering (DLS) component DLS(A1(t)) that is indicative of a first DLS measurement;
c) detecting the light field signal LF(x2, y2, z2) prevailing at a second location (x2, y2, z2) to generate a second analog electrical signal A2(t), the second analog electrical signal A2(t) including a DLS component DLS(A2(t)) that is indicative of a second DLS measurement and that is uncorrelated with the DLS component of the first analog signal A1(t);
d) processing, by analog electrical circuitry, the first and second analog electrical signals to generate a processed analog electrical signal processed(t) from a difference between the first and second analog electrical signals, wherein:
(i) a first DLS contribution ratio

DLS
⁡
(
A
1
⁡
(
t
)
)


A
1
⁡
(
t
)

is defined as the ratio between a magnitude |DLS(A1(t))| of the DLS component of the first analog electrical signal and a magnitude |A1(t)| of the first electrical analog signal;
(ii) a second DLS contribution ratio

DLS
⁡
(
A
2
⁡
(
t
)
)


A
2
⁡
(
t
)

is defined as the ratio between a magnitude |DLS(A2(t))| of the DLS component of the second analog electrical signal and a magnitude |A2(t)| of the second analog electrical signal;
(iii) processed analog electrical signal processed(t) includes a DLS component that is indicative of a combination of the first and second dynamic scattering measurements;
(iv) a processed signal DLS contribution ratio

DLS
⁡
(
processed
⁡
(
t
)
)


processed
⁡
(
t
)

is defined as a ratio between a (i) magnitude |DLS(processed(t))| of the DLS component of the processed analog electrical signal and (ii) a magnitude |processed(t)| of the processed analog signal;
and
(v) the detecting and the processing are performed so that a ratio between:
i) the processed signal DLS contribution ratio

DLS
⁡
(
processed
⁡
(
t
)
)


processed
⁡
(
t
)

;
ii) at least one of the first DLS contribution ratio

DLS
⁡
(
A
1
⁡
(
t
)
)


A
1
⁡
(
t
)

and the second DLS contribution ratio

DLS
⁡
(
A
2
⁡
(
t
)
)


A
2
⁡
(
t
)

is at least 10.

131 more elements

Dependencies are inferred from the claim text.

Facts

Application: 12/774,056Filed 5 May 2010 · us provisional application
Priority: 6 May 2009
Published: US 2010/0286497 A111 Nov 2010
Granted: 29 Apr 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61B 5/0261
Measuring blood flow: using optical means, e.g. infrared light
A61B 5/02241
Occluders specially adapted therefor: of small dimensions, e.g. adapted to fingers
A61B 5/14535
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…
A61B 5/14546
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…

Family

Application61/175,981Us provisional application · filed 6 May 2009
US 2010/0286497 A1Pre-grant publication · published 11 Nov 2010
US 8,708,907 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A method for obtaining physiological information from a subject in accordance with a light field whose intensity varies according to location, the method comprising:

a) applying partially or entirely coherent light to a target region of the subject to induce a light response signal from the illuminated target region which contributes to a location-dependent light field LF(x, y, z);
b) detecting the light field LF(x1, y1, z1) prevailing at a first location (x1, y1, z1) to generate a first analog electrical signal A1(t), the first analog electrical signal A1(t) including a dynamic light scattering (DLS) component DLS(A1(t)) that is indicative of a first DLS measurement;
c) detecting the light field signal LF(x2, y2, z2) prevailing at a second location (x2, y2, z2) to generate a second analog electrical signal A2(t), the second analog electrical signal A2(t) including a DLS component DLS(A2(t)) that is indicative of a second DLS measurement and that is uncorrelated with the DLS component of the first analog signal A1(t);
d) processing, by analog electrical circuitry, the first and second analog electrical signals to generate a processed analog electrical signal processed(t) from a difference between the first and second analog electrical signals, wherein:
(i) a first DLS contribution ratio

DLS
⁡
(
A
1
⁡
(
t
)
)


A
1
⁡
(
t
)

is defined as the ratio between a magnitude |DLS(A1(t))| of the DLS component of the first analog electrical signal and a magnitude |A1(t)| of the first electrical analog signal;
(ii) a second DLS contribution ratio

DLS
⁡
(
A
2
⁡
(
t
)
)


A
2
⁡
(
t
)

is defined as the ratio between a magnitude |DLS(A2(t))| of the DLS component of the second analog electrical signal and a magnitude |A2(t)| of the second analog electrical signal;
(iii) processed analog electrical signal processed(t) includes a DLS component that is indicative of a combination of the first and second dynamic scattering measurements;
(iv) a processed signal DLS contribution ratio

DLS
⁡
(
processed
⁡
(
t
)
)


processed
⁡
(
t
)

is defined as a ratio between a (i) magnitude |DLS(processed(t))| of the DLS component of the processed analog electrical signal and (ii) a magnitude |processed(t)| of the processed analog signal;
and
(v) the detecting and the processing are performed so that a ratio between:
i) the processed signal DLS contribution ratio

DLS
⁡
(
processed
⁡
(
t
)
)


processed
⁡
(
t
)

;
ii) at least one of the first DLS contribution ratio

DLS
⁡
(
A
1
⁡
(
t
)
)


A
1
⁡
(
t
)

and the second DLS contribution ratio

DLS
⁡
(
A
2
⁡
(
t
)
)


A
2
⁡
(
t
)

is at least 10.

131 more elements

Facts

Application

12/774,056Filed 5 May 2010 · us provisional application

Priority

6 May 2009

Published

US 2010/0286497 A111 Nov 2010

Granted

29 Apr 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61B 5/0261
Measuring blood flow: using optical means, e.g. infrared light
A61B 5/02241
Occluders specially adapted therefor: of small dimensions, e.g. adapted to fingers
A61B 5/14535
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…
A61B 5/14546
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…