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US 8,703,987 B2Granted
Methods for preparing 2-methoxyisobutylisonitrile and tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate
AssigneeDraximage Limited
InventorPierre Morel
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Abstract
The present invention relates to new synthetic methods for preparing 2-methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate, which are used in the preparation of technetium (99mTc) Sestamibi, and novel intermediate compounds useful in such methods.
Claims5
A method of preparing 2-methoxyisobutylisonitrile comprising the steps of:
- (a) converting 2,2-dimethyloxirane to 2-methoxyisobutanol,
- (b) converting 2-methoxyisobutanol to 2-methoxyisobutylamine;
- (c) converting the 2-methoxyisobutylamine of step (b) to a compound of the formula
- where X is halogen, and
- (d) converting the compound of formula (4) to 2-methoxyisobutylisonitrile, wherein step (a) comprises adding 2,2-dimethyloxirane to a solution of acid in methanol, and step (b) comprises:
- (1) reacting 2-methoxyisobutanol with (1) triphenylphosphine, (2) phthalimide, and (3) diethylazodicarboxylate (DEAD) or diisopropylazodicarboxylate (DIAD), to form a compound having the formula
- (2) reacting the product of step (1) without purification with hydrazine to form 2-methoxyisobutylamine.
4 more elements
Dependencies are inferred from the claim text.