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US 8,703,829 B2Granted
Therapeutic compounds
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsGerald B. Hammond, Bo Xu, Paula J. Bates
Life of this patent
Estimating the term…
Abstract
The invention provides compounds of Formula (I): R1≡R2 (I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
Claims19
A method for treating cancer in an animal comprising administering to the animal a compound of Formula (II):
- wherein:
- R3 is hydroxy, mercapto, chloro, bromo, methylthio, ethylthio, methoxy, ethoxy, acetylamino, (C1-C20)alkanoyloxy, arylcarbonyloxy, or aryloxy;
- and R4 is (C4-C10)alkyl, (C2-C10)alkenyl, or (C2-C10)alkynyl, which (C4-C10)alkyl, (C2-C10)alkenyl, or (C2-C10)alkynyl is optionally substituted with one or more groups independently selected from halo, hydroxy, mercapto, (C1-C10)alkoxy, (C1-C10)alkylthio, carboxy, (C1-C10)alkoxycarbonyl, aryl, heteroaryl, and NRaRb;
- each Raand Rb is independently H, (C1-C20)alkyl, (C1-C20)alkanoyl, (C2-C20)alkenylcarbonyl, (C2-C20)alkynylcarbonyl, (C1-C20)alkoxy, (C2-C20)alkenyloxy, (C2-C20)alkynyloxy, or aryl-(C1-C20)alkoxycarbonyl;
- or a pharmaceutically acceptable salt thereof,
- wherein the cancer is breast cancer, prostate cancer, colon cancer, brain cancer, or non-small cell lung cancer.
3 more elements
A method for inhibiting methyltransferase activity,
- wherein the method comprises administering an effective amount of a compound of Formula (II):
- wherein:
- R3 is hydroxy, mercapto, chloro, bromo, methylthio, ethylthio, methoxy, ethoxy, acetylamino, (C1-C20)alkanoyloxy, arylcarbonyloxy, or aryloxy;
- and R4 is (C4-C10)alkyl, or (C2-C10)alkynyl, which (C4-C10)alkyl, (C2-C10)alkenyl, or (C2-C10)alkynyl is optionally substituted with one or more groups independently selected from halo, hydroxy, mercapto, (C1-C10)alkoxy, (C1-C10)alkylthio, carboxy, (C1-C10)alkoxycarbonyl, aryl, heteroaryl, and NRaRb;
- each Ra and Rb is independently H, (C1-C20)alkyl, (C1-C20)alkanoyl, (C2-C20)alkenylcarbonyl, (C2-C20)alkynylcarbonyl, (C1-C20)alkoxy, (C2-C20)alkenyloxy, (C2-C20)alkynyloxy, or aryl-(C1-C20)alkoxycarbonyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.