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US 8,703,439 B1Granted
Point of care iodine sensor
OwnerLinda Lesterinventor
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Abstract
Methods and devices for use in detecting the iodine status of a subject are provided. The methods and devices utilize an iodide binding protein (IBP) to specifically bind to and facilitate detection of iodide in a saliva sample from a subject. The detected iodide can be used to detect the iodide status of the subject. In several examples, the IBP includes an iodide binding domain from a vanadium dependent iodoperoxidase (vIPO), including a catalytically inactive vIPO.
Claims12
A test device for detecting iodide in saliva, the test device comprising:
- a sample receiving zone;
- and
- an iodide capture zone comprising an iodide binding protein that specifically binds to iodide, wherein the iodide binding protein comprises a vanadium-dependent iodoperoxidase comprising the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- wherein the sample receiving zone is coupled to the iodide capture zone, and wherein application of a liquid saliva sample to the sample receiving zone results in application of the liquid saliva sample to the iodide capture zone and binding of iodide in the liquid saliva sample to the IBP.
3 more elements
Dependencies are inferred from the claim text.