Hemostatic sponge
AssigneeBaxter International Inc.
InventorsHans Christian Hedrich, Joris Hoefinghoff
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Abstract
The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.
Claims36
A hemostatic porous composite sponge, comprising:
- a matrix of a biomaterial;
- and
- a single hydrophilic polymeric crosslinker comprising reactive groups,
- wherein the matrix and the single hydrophilic polymeric crosslinker are associated with each other so that:
- the reactivity of the hydrophilic polymeric crosslinker is retained, and
- the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix, or the matrix is impregnated with the single hydrophilic polymeric crosslinker, or both.
A method of treating an injury, comprising:
- administering a hemostatic porous composite sponge to the injury, the sponge comprising:
- a matrix of a biomaterial;
- and
- a single hydrophilic polymeric crosslinker comprising reactive groups,
- wherein the matrix and the single hydrophilic polymeric crosslinker are associated with each other so that:
- the reactivity of the single hydrophilic polymeric crosslinker is retained, and
- the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix, or the matrix is impregnated with the single hydrophilic polymeric crosslinker, or both, and
- wherein the injury comprises a member selected from the group consisting of a wound, a hemorrhage, a damaged tissue, and a bleeding tissue.
A kit, comprising:
- a hemostatic porous composite sponge, comprising:
- a matrix of a biomaterial;
- and
- a single hydrophilic polymeric crosslinker comprising reactive groups,
- wherein the matrix and the single hydrophilic polymeric crosslinker are associated with each other so that:
- the reactivity of the single hydrophilic polymeric crosslinker is retained, and
- the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix, or the matrix is impregnated with the single hydrophilic polymeric crosslinker, or both;
- a buffer solution;
- and
- instructions for using the hemostatic porous composite sponge and the buffer solution.
A hemostatic composite, comprising:
- a haemostatic material;
- and
- a single hydrophilic polymeric crosslinker with reactive groups associated with the haemostatic material such that the reactivity of the single hydrophilic polymeric crosslinker is retained,
- wherein the composite comprises pore which allow external fluids to access into the composite.
Dependencies are inferred from the claim text.