Back to results
US 8,703,133 B2Granted
Antibody variants
AssigneeGenentech, Inc.
InventorsYvonne M. Chen, Henry B. Lowman, Yves Muller
Life of this patent
Estimating the term…
Abstract
Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
Claims2
An isolated antibody variant of the humanized anti-VEGF antibody F(ab)-12, wherein the light chain variable domain of F(ab)-12 comprises the amino acid sequence of SEQ ID NO:
- 94 and the heavy chain variable domain of F(ab)-12 comprises the amino acid sequence of SEQ ID NO:96, and wherein the CDR H3 for the antibody variant is substituted with one of an amino acid sequence selected from the group consisting of SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:78, SEQ ID NO:86, and SEQ ID NO:89.
Dependencies are inferred from the claim text.