Back to results
US 8,703,132 B2Granted
Bispecific, tetravalent antigen binding proteins
AssigneeHoffmann-La Roche Inc.
InventorsSabine Imhof-Jung, Christian Klein, Joerg Thomas Regula, Wolfgang Schaefer, Juergen Michael Schanzer
Life of this patent
Estimating the term…
Abstract
The present invention relates to bispecific, tetravalent antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Claims11
A bispecific, tetravalent antigen binding protein, comprising:
- a) a first heavy chain of a first antibody, wherein said first antibody specifically binds to a first antigen, and wherein said first heavy chain is fused through its C-terminus to the N-terminus of a moiety comprising VH-CH1 domains of said first antibody;
- b) two light chains of said first antibody of a);
- c) a second heavy chain of a second antibody, wherein said second antibody specifically binds to a second antigen, wherein said second heavy chain is fused through its C-terminus to the N-terminus of a moiety comprising VH-CL domains of said second antibody, and wherein the CH1 domain of said second heavy chain is replaced by the CL domain of said second antibody;
- and
- d) two second light chains of said second antibody of c),
- wherein the CL domain of each of said second light chains is replaced by the CH1 domain of said second antibody.
3 more elements
Dependencies are inferred from the claim text.