Composition for photodynamic disinfection
AssigneeOndine International, Ltd.
InventorsCale Street, Lisa Pedigo, Nicolas Loebel
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Abstract
The present invention includes a composition for enhancing the antimicrobial efficacy of photodynamic disinfection against Gram-negative organism that is receptive to paraben potentiation using a composition comprising a photosensitizer and at least one paraben. The present invention also includes a method for photodynamic disinfection comprising applying the composition to a desired treatment area and applying light to the desired treatment area at a wavelength absorbed by the photosensitizer so as to inhibit Gram-negative organism located within the treatment area wherein the Gram-negative organism is receptive to paraben potentiation.
Claims13
A composition for photodynamic disinfection comprising:
- a phenothiazinium salt at a concentration ranges from about 0.001% w/v to about 1% w/v, and propylparaben at a concentration ranges from about 0.001% w/v to about 1 w/v, wherein (i) the composition is used for photodynamic disinfection of Gram-negative organism that is receptive to paraben potentiation and is located within a desired treatment area;
- and (ii) the composition provides the paraben potentiation against the Gram-negative organism during photodynamic disinfection of the Gram-negative organism by enhancing the antimicrobial efficacy of the phenothiazinium salt against the Gram-negative organism during the photodynamic disinfection.
The composition of claim herein the photosensitizer is methylene blue.
A method to enhance antimicrobial efficacy of a phenothiazinium salt against Gram-negative organism during photodynamic disinfection comprising:
- a. Applying a composition comprising (i) a phenothiazine salt at a concentration ranges from about 0.001% w/v to about 1% w/v;
- and (ii) propylparaben at a concentration ranges from 0.001% w/v to 1% w/v to a desired treatment area, and
- b. Applying light to the desired treatment area at a wavelength absorbed by the phenothiazinium salt so as to inhibit the Gram-negative organism located within the desired treatment area wherein (i) the Gram-negative organism is receptive to paraben potentiation;
- (ii) the composition provides the paraben potentiation against the Gram-negative organism by enhancing the antimicrobial efficacy of the phenothiazinium salt against the Gram-negative organism during the photodynamic disinfection.
Dependencies are inferred from the claim text.