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US 8,697,854 B2Granted
High affinity T cell receptor and use thereof
AssigneeHelmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
InventorsDolores Schendel, Susanne Wilde, Bernhard Frankenberger, Wolfgang Uckert
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Abstract
The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same, a T cell expressing said TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.
Claims2
An isolated nucleic acid molecule coding for the V(D)J regions of a T cell receptor (TCR) that recognizes tyrosinase and comprising the nucleic acid sequence of SEQ ID NO:
- 1 coding for the α-chain and/or the nucleic acid sequence of SEQ ID NO:
- 2 coding for the β-chain of said TCR, or
- a derivative thereof, wherein the α- and β-chain coding sequence is derived from SEQ ID NO:
- 1 and SEQ ID NO:
- 2, respectively, by codon optimization,
- or
- a fragment thereof coding for a CDR3 region of a TCR recognizing tyrosinase and having the nucleic acid sequence of SEQ ID NO:
- 3 or 4 or coding for the amino acid sequences of SEQ ID NO:
- 5 or 6.
6 more elements
Dependencies are inferred from the claim text.