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US 8,697,688 B2Granted
Pyrrolobenzodiazepines used to treat proliferative diseases
AssigneesSeattle Genetics, Inc., Spirogen Sarl
InventorsPhilip Wilson Howard, Luke Masterson, Arnaud Tiberghien, Scott Jeffrey, Patrick Burke, Peter Senter
Life of this patent
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Abstract
Pyrrolobenzodiazepine dimers I having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds.
Claims7
A compound with the formula I:
- wherein:
- R2 is of formula III:
- Where A is —C6H4—, X is NHRN, wherein RN is H, and Q1 is a single bond, and Q2 is a single bond;
- R12 is selected from:
- (iia) methyl;
- (iib) cyclopropyl;
- (iic)
- wherein R21 and R22 are hydrogen and R23 is methyl;
- (iid)
- wherein R25b is H and R25a is phenyl;
- and
- (iie)
- wherein R24 is H;
- R6 and R9 are H;
- Where R is independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups;
- R7 is OH or OR;
- R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound;
- R″ os a C3 alkylene group;
- Y and Y′ are O;
- R6, R7′, R9′ are selected from the same groups as R6, R7, and R9 respectively and R10′ and R11′ are the same as R10 and R11.
17 more elements
Dependencies are inferred from the claim text.