Baculoviral vectors comprising repeated coding sequences with differential codon biases

An insect cell comprising a baculoviral vector comprising:

• (i) a first nucleotide sequence encoding a first amino acid sequence of a parvoviral Rep52 protein and is selected from the group consisting of:
• (a) SEQ ID NO:1;
• (b) SEQ ID NO:5;
• (c) A sequence of at least 75% identity with SEQ ID NO:2;
• (d) A sequence of at least 60% identity with SEQ ID NO:3;
• (e) A sequence of at least 70% identity with SEQ ID NO:4;
• (f) A sequence of at least 85% identity with SEQ ID NO:10;
• (g) A nucleotide sequence complementary to the full length sequence of any of (a)-(f);
• and
• (h) A nucleotide sequence that differs from the sequence of any of (c)-(f) due to degeneracy of the genetic code;
• and
• (ii) a second nucleotide sequence encoding a second amino acid sequence of a parvoviral Rep78 protein or a Rep68 protein,
• wherein the first and the second amino acid sequences comprise a homologous region of at least 100 amino acid residues with at least 90% identity beginning at the second residue and ending at the C-terminal residue of the parvoviral Rep 52, and
• wherein the portion of the first nucleotide sequence that encodes the homologous region and the portion of the second nucleotide sequence that encodes the homologous region are less than 90% identical.