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OwnerNigel H. Greig, Karen T. Y. Shaw +10inventors
InventorsNigel H. Greig, Karen T. Y. Shaw, Qiang-Sheng Yu, Harold W. Holloway, Tada Utsuki, Timothy T. Soncrant, Donald K. Ingram, Arnold Brossi, Anthony Giordano, Gordon Powers, Diane M. Davidson, Michael Sturgess
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The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
A method of inhibiting production of amyloid precursor protein in a mammalian subject in need thereof, the method comprising administering parenterally to the mammalian subject an effective amount of a pharmaceutical composition comprising (+)-phenserine.
A method of treating dementia in a mammalian subject in need thereof, the method comprising administering parenterally to the mammalian subject an effective amount of a pharmaceutical composition comprising (+)-phenserine.
Dependencies are inferred from the claim text.