Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof
AssigneeCrucell Holland B.V.
InventorsEdward Norbert Van Den Brink, Cornelis Adriaan De Kruif, Mark Throsby
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Abstract
Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
Claims12
An isolated binding molecule able to recognize and bind to an epitope in the HA2 subunit of the influenza hemagglutinin protein (HA), wherein the binding molecule has neutralizing activity against an influenza virus comprising HA of the H5 subtype, wherein the binding molecule comprises a heavy chain CDR1 region of SEQ ID NO:
- 1, a heavy chain CDR2 region of SEQ ID NO:
- 2, a heavy chain CDR3 region of SEQ ID NO:
- 3, a light chain CDR1 region of SEQ ID NO:
- 13, a light chain CDR2 region of SEQ ID NO:
- 14, and a light chain CDR3 region of SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.