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US 8,686,177 B2Granted
LPA receptor agonists and antagonists
AssigneeRxBio, Inc.
InventorVeeresh Gududuru
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
Claims2
A composition comprising a compound of formula (I)
- wherein,
- X1 is R1—Y1-A-;
- X2 is —Z1—P(S)(OH)2;
- X3 is hydrogen;
- A is a direct link or (CH2)l with l being an integer from 1-30;
- Y1 is (CH2)l with l being an integer from 1-30;
- Z1 is oxygen;
- Q1 and Q2 are independently selected from the group consisting of H2, ═NR4, ═O, or a combination of H and —NR5R6;
- R1 is independently a straight or branched-chain C1 to C30 alkyl substituted with one or more cycloalkyl or a straight or branched-chain C2 to C30 alkenyl substituted with one or more cycloalkyl;
- and
- R4, R5, and R6, are independently hydrogen, a straight or branched-chain C1 to C30 alkyl, or a straight or branched-chain C2 to C30 alkenyl.
8 more elements
Dependencies are inferred from the claim text.