Pyrimidine cyclohexyl glucocorticoid receptor modulators

A compound of formula I:

• wherein
• the dashed line is absent or a bond;
• X is selected from the group consisting of O and S;
• R1 is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl, optionally substituted with from 1 to 3 R1a groups;
• each R1a is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl,
• C2-6 alkynyl, C1-6 alkoxy, C1-6 alkyl-OR1b, halogen, C1-6 haloalkyl,
• C1-6 haloaloxy, —OR1b, —NR1bR1c, —C(O)R1b, —C(O)OR1b, —OC(O)R1b, —C(O)NR1bR1c, —NR1bC(O)R1c, —SO2R1b, —SO2NR1bR1c, cycloalkyl, heterocycloalkyl, aryl and heteroaryl;
• R1b and R1c are each independently selected from the group consisting of H and C1-6 alkyl;
• R2 is selected from the group consisting of H, C1-6 alkyl, C1-6 alkyl-OR1b, C1-6 alkyl-NR1bR1c and C1-6 alkylene-heterocycloalkyl;
• R3 is selected from the group consisting of H and C1-6 alkyl;
• Ar is aryl, optionally substituted with 1-4 R4 groups;
• each R4 is independently selected from the group consisting of H, C1-6 alkyl, C1-6 alkoxy, halogen, C1-6 haloalkyl and C1-6 haloalkoxy;
• L1 is a bond or C1-6 alkylene;
• subscript n is an integer from 0 to 3,
• and salts and isomers thereof.