Therapeutic and surgical treatment method for providing cardiopulmonary and circulatory assist device
AssigneesGui Fu Wu, Pierre Chastanier
InventorSayed Nour
Life of this patent
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Abstract
The present disclosure relates to a therapeutic method for improving the hemodynamics, the overall microcirculation in organs, and the restoration and preservation of deficient endothelial function in a patient, the method includes maintaining blood circulation in the patient's veins and arteries and temporarily relieving the heart of its pumping function. Relief may be accomplished by increasing the preload of the right ventricle so as to improve oxygenation of the myocardium and its contractility, reducing and diffusing regular pulsations in the proximity of the aortic root so as to improve the hemodynamics of the left ventricle of the heart, and/or mechanically stimulating the endothelium by shear forces so as to reduce systemic and pulmonary afterload.
Claims16
A therapeutic method for improving overall microcirculation in organs, for improving hemodynamics, for restoring and preserving deficient endothelial function in a diseased patient, the method comprising:
- maintaining circulatory flow dynamics of blood in systemic and pulmonary circuits of the diseased patient;
- and
- temporarily relieving a pumping function of a heart of the diseased patient;
- wherein the method further comprises using at least one device external to a body of the diseased patient and connected via a connection element, to:
- increase a preload of a right ventricle of the heart so as to improve myocardium oxygenation and its contractility;
- or
- unload a left ventricle of the heart and diffuse regular pulsatile flow in a proximity of an aortic root of the heart so as to improve hemodynamics of the left ventricle;
- or
- stimulate an endothelium of the diseased patient mechanically by shear stress enhancement so as to reduce afterload of the systemic and pulmonary circuits and release several mediators of endothelial vasodilators, in such a manner as to improve microcirculation of main vital organs of the diseased patient by means of the several endothelial vascular vasodilators mediators secreted in particular in response to an application of quasi-physiological tangential forces of shear stresses on endothelial walls of the diseased patient.
A therapeutic method for improving overall microcirculation in organs, improving hemodynamics, and restoring and preserving deficient endothelial function in a patient, the method comprising:
- maintaining circulatory flow dynamics of blood in systemic and pulmonary circuits of the patient;
- and
- temporarily relieving a pumping function of a heart of the patient in such a manner as to improve microcirculation of main vital organs of the patient by means of a plurality of endothelial vascular vasodilators mediators secreted in particular in response to an application of quasi-physiological tangential forces of shear stresses on endothelial walls of the patient, wherein the method further comprises using at least one device external to a body of the diseased patient and connected via a connection element.
A therapeutic method for improving overall microcirculation in organs, improving hemodynamics, and restoring and preserving deficient endothelial function in a patient, the method comprising:
- improving oxygenation of a myocardium of the patient by increasing a preload of a right ventricle of the patient and improving its contractility;
- unloading a left ventricle of the patient and diffusing regular pulsatile flow in a proximity of an aortic root of the patient so as to improve hemodynamics of the left ventricle of the heart;
- and
- stimulating the patient's endothelium mechanically by shear stress enhancement so as to reduce systemic and pulmonary afterload and so as to release a plurality of mediators of endothelial vasodilators, in a manner sufficient such that microcirculation of the main vital organs of the patient is improved by the plurality of endothelial vascular vasodilators mediators secreted in response to an application of quasi-physiological tangential forces of shear stresses on endothelial walls of the patient.
Dependencies are inferred from the claim text.