Immunoglobulin constant region FC receptor binding agents
AssigneesGliknik Inc., University of Maryland, Baltimore
InventorsScott E. Strome, Dan H. Schulze, David S. Block, Henrik Olsen
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Abstract
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.
Claims15
A cluster stradomer comprising two or more multimerized cluster stradomer units, wherein each of said cluster stradomer units comprises at least one multimerizing region and at least one Fc domain, wherein the multimerizing region(s) of the two or more cluster stradomer units multimerize to form the cluster stradomer, wherein the cluster stradomer is capable of specifically binding to at least two Fc receptors;
- wherein the at least one multimerizing region is an IgG2 hinge or an isoleucine zipper;
- and wherein the at least one Fc domain comprises a CH2 domain and a CH3 domain from IgG1 or IgG3 or a combination thereof.
A cluster stradomer comprising two or inure multimerized cluster stradomer units, wherein each of said cluster stradomer units comprises an IgG2 hinge multimerizing region and an IgG1 Fc domain comprising a CH2 and CH3 domain, wherein the IgG2 hinge multimerizing region of the two or more cluster stradomer units multimerize to form the cluster stradomer, and wherein the cluster stradomer is capable of specifically binding to at least two Fcγ receptors.
A cluster stradomer comprising two or more multimerized cluster stradomer units, wherein each of said cluster stradomer units comprises an isoleucine zipper multimerizing region and an IgG1 Fc domain comprising a CH2 and CH3 domain, wherein the isoleucine zipper multimerizing region of each of the two or more cluster stradomer units multimerize to form the cluster stradomer, and wherein the cluster stradomer is capable of specifically binding to at least two Fcγ receptors.
Dependencies are inferred from the claim text.