Back to results
US 8,680,068 B2Granted
Herpes virus strains
AssigneeBiovex Limited
InventorRobert S. Coffin
Life of this patent
Estimating the term…
Abstract
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene.
Claims5
A method of treating cancer in an individual in need thereof by administering to a tumor via direct intratumoral injection a therapeutically effective amount of a herpes simplex virus which:
- (i) comprises a gene encoding human GM-CSF;
- (ii) lacks a functional ICP34.5 encoding gene and a functional ICP47 encoding gene;
- and (iii) is replication competent in infected tumor cells, wherein said herpes simplex virus is HSV1 strain JSI as deposited in the European Collection of Cell Cultures (ECACC) under accession number 01010209.
Dependencies are inferred from the claim text.