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US 8,679,776 B2Granted
Activatable dyes
AssigneeUniversity of Massachusetts
InventorStephen C. Miller
Life of this patent
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Abstract
Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision.
Claims11
A compound represented by Structure VI:
- wherein
- X is O, S, NH, or CR23R24,
- R30 and R31 are each independently H, alkyl, alkenyl, alkaryl, aryl, a bis-arsenical spirolactam group, a NHS ester group, a maleimide group, or an iodoacetamide group, each of alkyl, alkenyl, alkynyl, and aryl comprising up to 36 carbon atoms,
- R11-R24 are each independently H, F, Cl, Br, I, OH, alkyl, alkenyl, alkynyl, or aryl, each of alkyl, alkenyl, alkynyl, and aryl comprising up to 36 carbon atoms, and
- G is selected from the group consisting of
2 more elements
A compound represented by:
Dependencies are inferred from the claim text.